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Description

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

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Along with its role in lowering blood glucose levels, LIXI has many other functions, such as cardiovascular benefits, delaying gastric emptying, protective effect on pancreatic beta-cells, and increased insulin mRNA expression and hormone secretion (65)

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Importantly, preclinical studies demonstrated that the synergistic effect of GIPRAs and GLP-1RAs on body weight requires the GABAergic (GABA refers to gamma-aminobutyric acid) GIPR-expressing neurons in the CNS [21, 28]

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