Cannabis may increase diabetes risk by promoting insulin resistance and unhealthy eating habits
In an oxidative ER environment, activated ERO1 generates disulfide bonds by consuming O 2 in the presence of flavin cofactors, which are then passed to the protein for folding via PDI (Wang et al., 2014)
The automated microscopy approach we used to demonstrate this has certain advantages over lower throughput methods, by allowing responses to a wide range of ligands or, in this case, ligand concentrations to be monitored in parallel across several FOVs, characterising ligand effects in more detail and with greater statistical robustness
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In addition, patients who experience intolerable side effects are unlikely to benefit from switching to a therapy with similar effects on the gastrointestinal tract
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