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It also has the consequence of a specific metabolic activation of BAT to increase or sustain energy expenditure in the face of decreased food intake to burn off mobilized adipose tissue, that in part aids the reduction in hepatic steatosis

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The resultant opening of voltage-dependent L-type Ca 2+ channels increases the intracellular concentration of Ca 2+ , which also acts as a second messenger, augmenting neurotransmitter release [33]