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The trial showed that tirzepatide achieved roughly 20% weight loss (about 50 pounds) versus 14% weight loss (33 pounds) with semaglutide. This significant difference prompted analysts to declare tirzepatide the winner. As a result, clinicians are updating treatment algorithms and patients on semaglutide are asking about switching

[7] Where the skin is involved, there may be radiating rhagades (linear fissures) from the corner of the mouth

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By creating a side-to-side anastomosis between the jejunum and ileum, it shortens the food transit time, allowing undigested nutrients to rapidly reach the distal ileum

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This 72-hour window is a critical safety threshold