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47,48,49 Additionally, deletion of Pik3r1 and Pik3r2 that encode PI3K subunit isoforms in skeletal muscle inhibits insulin-stimulated glucose transport

The adverse effect of elevated blood sugar on the glycocalyx is a primary reason why diabetes dramatically increases the risk of heart disease

That fact alone does not tell you what to do, but it does explain why some people pause or choose a different option

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