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Zhao et al., 2025b)

7, 8 Normal human pancreas as well as the chronically inflamed pancreas express GLP1R, as expected, primarily in the therapeutic targets of GLP1 analogs, namely the insulin-producing cells

The prior recommendations only account for medication changes while everything else remains constant

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Tirzepatide also activates the GIP receptor and is associated with higher average weight loss in trials, while semaglutide has a longer track record and may suit patients who prefer a single-receptor approach