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Cytokine profiling using immunology multiplex assay MCP-1/CCL2, IL-6, and TNF-alpha (TNF) were measured in fasted plasma collected at endpoint using the Milliplex MAP Mouse Metabolic Hormone Magnetic Bead Panel in the Luminex MAGPIX system (EMD Millipore, Billerica, MA)

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Contact dermatitis (redness, irritation, itchiness, rashes) is the most common side effect, especially for sensitive skin

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