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Across multiple STEP trials, the enrollment criteria required a BMI of 30 or higher, or 27 or higher with at least one weight-related comorbidity (excluding type 2 diabetes, which was studied separately)

The maximum liraglutide plasma concentration (Cmax) in overweight and obese subjects treated with liraglutide 3 mg is similar to the Cmax observed in the liraglutide QTc study in healthy volunteers

The stroke volume was obtained by averaging the calculated values from direct measurements of the cerebral images by two examiners as previously described [25]

The inhibition of system xc - significantly reduces GSH production, thereby decreasing GPX4 activity, leading to lipid ROS build-up and ultimately leading to ferroptosis (44)

B.AbzhanovaA.et al (2019)