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A separate 2024 meta-analysis (Alshammari et al.) confirmed the same conclusion, further strengthening the evidence base
Topical (T) Description : Medications are applied directly to the skin or mucous membranes
Folic acid is not a substitute for vitamin B12 although it may improve vitamin B12-deficient megaloblastic anemia
In the stomach, B12 is released from dietary proteins through the action of gastric acid and pepsin and initially binds to a protein called haptocorrin
This mechanism was documented in humans in 1984 by Bowers and confirmed in multiple clinical studies (Nass et al., J Clin Endocrinol Metab 2008)
Loren Pickart while studying wound healing
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