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Clinical Evidence for Targeting NAD Therapeutically

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Penelope Wilcock | Hastings | March 2026 Brilliant b12

Negative side effects may include a paradoxical decrease in energy levels (most likely due to detoxification from methylation) or slight pain at the injection site which diminishes over 5-10 days

In the UK, vitamin B12 deficiency is relatively common, particularly among older adults, vegans, vegetarians, and individuals with certain gastrointestinal conditions that impair absorption, such as pernicious anaemia or Crohn's disease

Some researchers use a small thermometer inside the fridge to monitor temperature