Clinical trial data consistently shows tirzepatide producing greater average weight loss than semaglutide, making this switch particularly relevant for patients whove plateaued, want stronger results, or havent responded adequately to semaglutide alone
This is largely driven by the GLP-1 receptor agonism
One hypothetical event I have not included is a small potential for Viking to announce their top-line weight loss data at the ADA conference in June26
Network meta-analyses suggest that higher-dose semaglutide (1 mg and 2 mg weekly) and tirzepatide (a dual GIP/GLP-1 receptor agonist) demonstrate superior A1c reductions compared to other agents in the class, with mean reductions of 1.52.0% or greater from baseline
Declaration: If asked, declare the medication
Vitamin B12 is an essential nutrient, and not produced by the body