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Research on obese mice suggests that unimolecular poly-pharmacology is an effective means to deal with various mechanisms leading to obesity and further indicates that GCGR activation is the distinguishing factor between single or double agonists and triple agonists of incretin receptors (127)

while Tirzepatide (515 mg), BI 456906 (1.84.8 mg) and Retatrutide (6.5 mg) demonstrated weight reduction effects exceeding 13 kg (Fig