This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier
It is in the same class as semaglutide, the active ingredient in Ozempic and Wegovy
120 to 240 mg EGb 761 daily, 12 to 24 weeks
For patients already taking GLP-1 medications, there is no need for alarm
You may wonder: glutathione injection vs IV whats the difference
Curcumin treats colitis in mice by balancing M1/M2 macrophage polarization and modulating TLR signaling (Kang et al., 2021)
