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For those with hypermobility and EDS specifically, Id flag the following as the minimum due diligence before starting these medications: A thorough GI history and ideally gastric emptying assessment if theres any existing dysmotility Baseline muscle mass measurement (DEXA or similar) given the sarcopenia risk A clear plan for high-protein diet and resistance-based exercise to mitigate muscle loss Baseline bone density if theres any existing concern Consideration of the nutritional picture specific to hypermobility, since these drugs can affect appetite and nutrient absorption A conversation specifically about MCAS if thats a feature of your presentation The medication options for hypermobility and EDS are limited and often unsatisfying, and its entirely understandable why people are looking at something new with genuine curiosity

But if fine lines look worse because skin is dehydrated, this kind of product can make them look softer fast

JAMA 323 3548

Tolerability and side effects : Starting at a lower dose and increasing gradually helps minimize potential side effects

The racing heart, shaky hands, and dry mouth before a big moment aren't nerves

Underdosing by using cheap filler is a real market problem