Tryptophan metabolites, including indole-3-lactic acid from Lactobacillus species activate GPR142 on L cells and promote the differentiation of intestinal stem cells toward the L cell lineage by upregulating transcription factors Math1, Neurog3, and Neurod1 while suppressing Notch signaling, making tryptophan metabolism a long-term structural regulator of GLP-1 secretory capacity, not merely an acute trigger
Lancet 2017;390:1664-75.ArticlePubMedPMC 83
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Vitamin B12 supplements can interact with some medications, too
Its also thought to help improve memory and cognitive skills, regulate internal body temperature, and stimulate pain relief and muscle development
The Semaglutide and Tirzepatide Data Gap For the newer medicationsSemaglutide and Tirzepatidewe have even less data: Semaglutide pregnancy data: For semaglutide, we only have limited case reports (like Case #2 above)