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It should be noted that patients who have previously responded to and tolerated antidepressants are rarely included in RCTs (where prior or current antidepressant use is usually an exclusion criterion), influencing the generalisability of results from placebo-controlled trials

In more severe cases of melasma, several treatment sessions scheduled over time may be necessary

doi: 10.1007/s13300-022-01218-y

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