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Appetite Suppression, Tolerability, and Long-Term Use The best GLP-1 medication is not necessarily the one associated with the greatest appetite suppression

Cell 177 , 146161 (2019)

Semaglutide, the active ingredient in Ozempic and Wegovy, activates only the GLP-1 receptor

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Because they hit different targets and the combination is stronger

The GLP-1RAs-associated weight loss is thought to be achieved through a variety of mechanisms, including the delayed gastric emptying, increased satiety, increased resting energy expenditure, as well as the direct influence of the appetite center of the brain (175)