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GYY4137, a HS donor, ameliorates kidney injuries in diabetic mice by modifying renal ROS-associated enzymes

We show delivery of proteinase K (PK), the low specificity protease also used for classical LiP, into living mammalian cells using an electroporation approach optimized to ensure rapid (millisecond) and reproducible intracellular uptake of the protease and the desired level of intracellular cleavage

Hepatology 60 , 20992108 (2014)

By the time you reach a stable maintenance dose, acid reflux is uncommon

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