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Unlike a glitazone medication like Actos (pioglitazone), which improves insulin sensitivity, GLP-1 agonists do not mainly work by directly unlocking insulin resistance the way a sensitizer doesalthough weight loss from GLP-1 therapy can indirectly improve insulin sensitivity
In March 2024, the Warnings and Precautions section for doctors in the monograph for Ozempic was updated to state that the Use of GLP-1 receptor agonists may be associated with severe gastrointestinal disease and that Events of delayed gastric emptying, dysgeusia and ileus have been reported
A 2025 study found iron deficiency in 88.4 per cent of Mounjaro users with hair loss
Functional and integrative approaches that focus on reducing inflammation, healing the gut, supporting mitochondria, and balancing the immune system can be life-changing
GLP-1 drugs have helped millions of Americans lose weight and get healthier, but have also been in short supply as brand-name drugmakers struggle to meet demand