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Upon DNA-dependent transactivation (TA), GR dimers bind to GC-responsive elements, followed by transcriptional activation of genes associated with an increased risk of adverse effects including diabetes mellitus, peptic ulcer, Cushings syndrome, osteoporosis, hyperglycemia, skin and muscle atrophy, and many other complications [12]

Retrieved 11 January 2023

[DOI] [PubMed] [Google Scholar] 7.Kozlowska U, Blume-Peytavi U, Kodelja V, et al

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& Csiszar, A