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Keywords: Acetaminophen, hepatotoxicity, molecular mechanisms, target, liver injury, oxidative stress Impact Statement With the widespread clinical use of acetaminophen (APAP), APAP-induced hepatotoxicity (AIH) has gradually become an important public health concern

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Protocol for the MPTP mouse model of Parkinsons disease

With regard to the protonation state of the leaving P i ion, only the simulation featuring HPO 4 2 is in agreement with the experimental cryo-EM density of the ADPP i state, whereas the simulation featuring H 2 PO 4 exhibits conformations and dynamics nearly identical to those of the ATP state (Extended Data Fig