The recent STRIDE trial evaluated semaglutide's impact on functional outcomes, revealing improved walking distance in patients with T2DM and symptomatic peripheral artery disease [3]
Congratulations Falk!
Like as long as I'm hitting my macros and I'm hitting my calories, nothing else matters
Think of it as a three-pronged metabolic signal to your body: stop eating so much, improve how your cells handle blood sugar, and ramp up fat burning at the same time
SGLT2 inhibitors (i.e., dapagliflozin) have been proven to strongly promote macrophage polarization towards a M2 phenotype, thus alleviating inflammation and atherosclerotic processes (Lee et al., 2020)
Mechanistically, AC countered DEN-induced oxidative stress and apoptosis through modulating STAT3, nuclear factor-kappa B (NF-B), Bax, cytochrome C, and Bcl-2 signaling (Peerzada et al