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Additional discussions, including comparisons with FDA drug labels and major clinical guidelines, are presented in Supplementary Materials 4

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When glucose levels are normal, the effect of insulin secretion is minimum which reduces the risk of hypoglycemia that frequently results from insulin therapy

Rotating injection sites on the abdomen, thigh, or upper arm prevents lipohypertrophy (fatty tissue buildup), which can alter drug absorption rates and create unpredictable blood sugar or appetite changes

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