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Upon activation, the tyrosine kinase activity of the IGF-IR entails sequential phosphorylation events at residues Y1135, Y1131, and Y1136, which produce conformational changes in the subunits to create docking sites for downstream signaling molecules and their phosphorylation (14)

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Importantly, these alterations were also observed in idiopathic RBD (iRBD) patients, representing the prodromal stage of PD

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It is not a true laser, but it works in a similar way for select concerns