318 Notch signaling pathway The Notch pathway is a conserved signaling pathway that plays roles in cell fate decisions, homeostasis maintenance, and liver regeneration
Wrzosek M, Winiewska K, Sawicka A, Taaaj M, Nowicka G
Many therapies now considered foundational in perioperative medicine were initially adopted based on mechanistic plausibility and early observational signals before high-quality surgical outcome trials were performed
Biomarkers were critical in the research leading to FDA approval of lecanemab and donanemab, both of which slow disease progression in individuals with mild symptoms
Rather than flooding synapses with a single neurotransmitter, it modulates the balance between serotonin, dopamine, and norepinephrine, nudging each toward optimal levels rather than artificially elevating one at the expense of others
This avoids the need to perform aseptic technique in non-ideal travel conditions