So averages were already increasing over time and that is the key factor to pay attention to here
Subjects were randomized to once-weekly tirzepatide or placebo in one of two trials
After washing, signal was detected using Clarity TM western -ECL substrate (Bio-Rad Laboratories, Inc)
65 In a meta-analysis by He et al, which included 76 RCTs covering more than 100,000 overweight or obese individuals, GLP-1 RA use was reported to increase the risk of gallbladder stones or biliary tract disease by 37% (RR 1.37 [95% CI 1.231.52])
They are arguing that the known risks were downplayed, buried in fine print, or left off the label entirely, leaving patients without the information they needed to make informed decisions
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