Each transition in our proposed algorithm is grounded in trial evidence, guideline thresholds, and comparative safety/efficacy profiles
Pathogenic factors such as lipotoxicity, insulin resistance, oxidative stress, and gut microbiota alterations contribute to both conditions
These metabolic disturbances activate several pathogenic pathways that contribute to neuronal dysfunction and death, ultimately manifesting as DPN
No time for the clinic
The answer, according to some experts, is maybe
3 Vitamins Vitamins are essential organic compounds needed in small amounts to support normal metabolic functions and health (Table 1) ( In oncology, the role of vitamins is particularly important (Table 3) ( In the following sections, we will provide an in-depth look at each vitamin and explore its specific role in cancer care