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Upper gastrointestinal bleeding risk increases when aspirin is combined with P2Y12 inhibitors such as clopidogrel, the drug name for Plavix (Antunes et al., 2024)

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and can result in "serious cardiometabolic complications, contributing to hypertension, coronary heart disease, stroke, heart failure, atrial fibrillation and type 2 diabetes," Lilly said

Thus, it is predicted that a dual agonist of both the incretin receptors might be more efficient in neuroprotection, than a single incretin agonist