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In addition, a recent Phase 3 trial (MAESTRO-NASH) including 966 patients with MASH demonstrated a MASH resolution with no worsening of fibrosis in 25.9% of the patients in the 80-mg resmetirom group and 29.9% of those in the 100-mg resmetirom group, as compared with 9.7% of the placebo group [38]

Common side effects and how to handle them Nausea is the most frequently reported side effect, especially during the first few weeks or after dose increases

Whats more, price differentials between countries, supply shortages, heavy cost-bearing for payers and legal scrutiny call for something to give

Galitzer who introduced me to this concept

By binding excess acyl groups, they help prevent toxic accumulation of acyl-CoA intermediates, particularly during metabolic stress or imbalances