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This response was more limited to the gut, so may have helped more in people with gastrointestinal issues like irritable bowel syndrome and Crohns

In experimental models it modulates angiogenesis (upregulating VEGF/VEGFR2 and the nitric oxide pathway), reduces pro-inflammatory cytokine signaling, supports fibroblast migration and collagen synthesis for connective-tissue repair, and influences gut-barrier integrity and neural pathways mechanisms that span musculoskeletal, gastrointestinal, and neurological tissue in preclinical research

Recently, both the FDA and the United States National Heart, Lung and Blood Institutes (NHLBI) have underscored the limitations of these measurements 7

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