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Mechanism literature Multiple peer-reviewed papers describe VEGFR2 activation, eNOS/NO signaling, and tendon-cell behavior in cultured cells and rodent models (Chang et al., Journal of Applied Physiology, 2011

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This peptide has been confirmed to promote rapid healing of damage to skin, soft tissue including tendons, ligaments and muscle fiber, and intestinal/internal tissue

Nanoparticles can also help to reduce toxicity

Eric Topol, director of the Scripps Research Translational Institute, has called the entire peptide craze unfounded

Because interaction data is sparse, underreported, and largely confined to preclinical rodent models