This multi-targeted approach explains why Wegovy produces more significant weight loss compared to lifestyle interventions aloneclinical trials have demonstrated average weight reductions of approximately 10-15% of initial body weight over 68 weeks in the STEP clinical trial programme
Final dose selection depends on individual tolerance, response, and provider judgment
The trial showed: Tirzepatide 5 mg: 7.6 kg weight loss Tirzepatide 10 mg: 9.3 kg weight loss Tirzepatide 15 mg: 11.2 kg weight loss Semaglutide 1 mg: 5.7 kg weight loss Some articles looked at those numbers and decided "tirzepatide 10 mg is roughly equivalent to semaglutide 1 mg" because 9.3 kg is about 1.6x more than 5.7 kg, and 10 mg is 10x more than 1 mg, so the "potency ratio" is around 6:1
The liver is the main control center that contains the enzymes to facilitate this process
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