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The most commonly reported side effects are mild and transient: injection site redness or minor bruising, transient fatigue in the first one to two weeks, and occasionally mild headache following the first few injections, a pattern sometimes attributed to the acute shift in cellular energy metabolism as AMPK pathways are upregulated [3]

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10.1038/ncomms7498 Summary Keywords gut microbiota, cardiovascular diseases, heart failure, metabolites, microbiota composition Citation Zhang Y, Wu H, Jin M, Feng G and Wang S (2025) The gut-heart axis: unveiling the roles of gut microbiota in cardiovascular diseases