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The X-ray-derived data of small molecular fragments in complex with TGR used in this study to design the compounds here described are available in the PDB under accession codes 6FTC, 6FMU, 6FMZ, 6FP4, 2X99, 2X8G, 2X8H, 6ZST, 6ZP3, 6ZLP, 6ZLB, 7B02, 7NPX, 2V6O, 6RTJ, 6RTO, 6RTM, and 3H4K
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As more research amplifies this connection, it paves the way for comprehensive treatment strategies that address physical and emotional health needs, offering hope for millions struggling with diabetes and associated mental health disorders
Recently, a new mechanism regulated by SCF FBXL4 -mediated ubiquitination of BNIP3 and NIX was reported [44]
( d ) NAO staining of mitochondrial mass in HT29 cells treated 5FU for 72 h, n = 3 biological replicates, with mean s.e.m
