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However, studies have not observed disruptions in -KG-dependent epigenetic activity, and -ketoglutarate supplementation does not rescue phagocytic defects in Gls1-deficient macrophages (Merlin et al., 2021)

Early Biochemical and Clinical Responses to Cobalamin Supplementation in Cats with Signs of Gastrointestinal Disease and Severe Hypocobalaminemia

J Nutr Biochem 85:108459

A #14 mutant with significantly higher glutathione content was isolated via acrolein resistance screening

The compound's fatty-acid modification introduces an oxidation-sensitive feature beyond standard peptide-bond hydrolysis pathways, so light protection matters more here than for unmodified peptide compounds