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The key question is not whether GLP-1-based therapy will eliminate the need for TKA, because many patients with advanced structural disease will still require surgery, but whether it can improve the route by which patients arrive there

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It was observed to prevent oncogenesis and even exert anti-tumor activity against allogeneic and syngeneic tumors, and prevent tumor metastasis

That means its default posture is toward FDA-approved commercial products filled through standard pharmacy channels