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This bifurcation Akt/mTORC1 for protein synthesis, ERK1/2 for proliferation represents the canonical dual anabolic output of IGF-1R activation, and both arms are relevant to skeletal muscle research depending on the biological question (hypertrophy vs regeneration)

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Patil SP, Wang J, Song Y, Noone S, Yang N, Wallenstein S, et al

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By pairing nitric oxide benefits with increased energy production, citrulline malate supports both muscle pumps and endurance

Gao Y, Liu Y, Liu Y, Peng Y, Yuan B, Fu Y, et al