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[1] [3] These include: Nausea and vomiting (particularly during dose escalation) Diarrhoea Reduced appetite and fluid intake When these symptoms are severe or prolonged, they can lead to dehydration , which reduces renal perfusion and may precipitate acute kidney injury (AKI)

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A 2026 JAMA Health Forum study of actual pharmacy claims found that once a branded medication hits an initial rejection at the pharmacy counter, the real end-to-end timeline centers around a median of 6 days for multi-day cases, with only 35 percent of prescriptions processed in 1 day

Discussion To our best knowledge, it is the first meta-analysis exploring the role of GLP1RAs in reproductive aspects of PCOS women