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Moreover, depression is characterized by high prevalence of coexistence with many metabolic diseases, such as type 2 diabetes mellitus (T2DM) and obesity, and brain insulin resistance observed in both of these diseases is currently considered an important factor which may lead to the manifestation of depressive symptoms [10, 11]

For best results on hyperpigmentation, it should be combined with good skincare (brightening creams, exfoliants, sun protection) and possibly other dermatologic treatments, depending on the severity of the issue