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5,288 However, most tumors upregulate PARP1 to support DNA damage, which is enhanced by radio- and chemotherapies
these are the primary targets for 505(b)(2) design-arounds
Some strategies, such as agonist HGF monoclonal antibodies, HGF gene transfer therapy, and HGF mimetics, may overcome the pharmacokinetic limitations
Sharma et al., 2021)
All eight reported studies have demonstrated the noninferiority of GLP-1RAs compared to placebo regarding MACE