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7 Therapeutic landscape & precision therapeutics 7.1 Established therapeutic pillars and their mechanistic foundations The management of DKD has undergone a substantial transformation with the emergence of four cornerstone pharmacological classes that consistently attenuate renal decline: inhibitors of the renin-angiotensin system (RAS) (Yaribeygi et al., 2021

Certain spore-forming gut bacteria stimulate intestinal serotonin production, which can alter signaling in the brain and has been linked to changes in mood and gastrointestinal motility [45]

Primers (Integrated DNA technologies, Singapore) used for PCR reactions were listed in Table 1

Cagrilintide adds a separate fullness signal that retatrutide does not hit on its own

Forsythia suspensa leaf fermented tea extracts attenuated oxidative stress in mice via the Ref-1/HIF-1 signal pathway and modulation of gut microbiota

Aim for 7 to 9 hours of sleep