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Most people tolerate these medications well, but some mild side effects are common as your body adjusts

For context, in one study of 175 people with overweight or obesity, participants taking semaglutide: Lost an average of 15 pounds (about 6% of their body weight) within three months Lost an average of 27 pounds (about 11% of their body weight) after six months Recommended lifestyle changes during GLP-1 therapy GLP-1 medications can boost weight loss by increasing satiety and reducing food cravings

Skin laxity is another concern with weight loss exceeding 15-20% of body weight

The main concern is that persistent nausea, vomiting, or diarrhea may cause dehydration and reduced kidney perfusion

Reed RL, Pearlmutter L, Yochum K, Meredith KE, Mooradian AD

Retrieved 12 July 2026