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StevensRDMarshallSACornblathDRHokeANeedhamDMde JongheBet al
Journal of Orthopaedic Research, 21(4), 753-758
Over-dosing frequency without mechanistic justification adds cost, increases injection site trauma in animal models, and complicates circadian confounding variables without improving endpoint sensitivity
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Higher concentrations dont have clearly better outcomes data and may cost more
Some patients report different side effect profiles between injection and oral formulations due to absorption rates and peak drug levels
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