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By improving overall metabolic health, reducing excess adiposity, and alleviating adipose tissue inflammation, tirzepatide could potentially mitigate upper airway collapsibility and ameliorate the underlying pathophysiological mechanisms of OSAS (27)

topline obesity data has been released this way for the entire class

Some lose significantly less than the trial averages

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Thus, suggesting that while individually, the DVC and the hypothalamus, appear to be sufficient to mediate the effects of GLP-1R agonists on energy balance, activation of multiple GLP-1R-responsive sites in the brain is necessary for endogenous GLP-1R regulation of feeding