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For example, some doctors make multiple injections in small amounts between the tendons, while others may make one large injection in the center of the hand, and then direct the filler to where it needs to go once its under the skin

Massage it into the skin so it reaches the area where it is meant to work

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However, treatment outcomes heavily depend on the practitioners expertise and can vary significantly from patient to patient

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doi: 10.3389/fmolb.2021.711227 239 SacconR