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Retatrutide also reduced liver triglyceride levels in preclinical studies of obese mice 11

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In a smaller cohort of patients with more severe CD phenotypes, including 17% with perianal involvement and 24% with penetrating or fistulizing disease, numerical reductions across outcomes were observed in the GLP-1RA group, but these differences did not reach statistical significance (104)

Drink 8-12 ounces immediately upon waking