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In 2017, a review 412 proposed disease modifying therapy for AD, which aims to intervene in the fundamental biological mechanisms to halt the diseases progression and provide enduring therapeutic benefits to patients

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However, with modern alternatives entering the scene, its time to reassess whether metformin still deserves its first-line status in 2026

Take 1 capsule daily with water

Short of that, the next best evidence will come from observational studies designed to emulate randomized trials

A febrile response (transient fever) may occur if aseptic technique isnt followed