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Because thyroid medication is absorbed in your stomach and small intestine, and semaglutide slows gastric emptying, delayed or incomplete absorption of levothyroxine could theoretically occur
In the head-to-head SURMOUNT-5 trial (NEJM 2025), tirzepatide produced 20.2% weight loss vs 13.7% for semaglutide
2,5,7,8,13 Exercise Physical activity enhances GLP-1 secretion and incretin sensitivity through improved L-cell responsiveness and metabolic signaling
The FDA shortage designation for semaglutide and tirzepatide - which originally provided the regulatory basis for much of the compounded GLP-1 market - has been resolved, and the FDA has proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list after stating it did not identify a clinical need for outsourcing facilities to compound those drugs from bulk substances
