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Meanwhile, it inhibits the phosphorylation of MAPK1 (ERK1/2) to block the proliferation of PASMCs, downregulates NOX4 to reduce ROS production for alleviating oxidative stress, and improves right ventricular fibrosis and energy metabolism by regulating the TGF-1/Bcl-2-Bax axis (Luo et al., 2021

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As a result, it aids male fertility

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