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This delivery format also supports longer research projects where consistency between trials remains essential

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Higher doses of vitamin B12 may be used to treat a clinically recognised deficiency

Besides the acute phase gastrointestinal effects which may lead to up to 10% of people discontinuing the drugs, there are other potential GI side effects of obstruction, excessive loss of muscle mass, and potentially association with some eye disease adverse events

Most researchers report initial changes between two and three months, with more substantial improvements visible at four to six months

This can minimize the risk of adverse reactions and maximize the efficacy of the treatment